Enzyme:6.2.1.12

Revision as of 09:00, 2 February 2009

4-coumarate:CoA ligase (AMP-forming)
Systematic Name	4-coumarate:CoA ligase (AMP-forming)
Common Name	4-coumarate-CoA ligase 4-coumaroyl-CoA synthetase p-coumaroyl CoA ligase p-coumaryl coenzyme A synthetase feruloyl CoA ligase

CoA + ATP + trans-4-Hydroxy-cinnamic acid => 4-Coumaroyl-CoA + AMP + Pyrophosphate
(links: CoA + ATP + trans-3- (4-Hydroxyphenyl) prop-2-enoic acid = 4-Coumaroyl-CoA + AMP)

CoA	<Mapping> AtomMap:BMCCPUAPf023$BMMCBZ2Pa016$0	4-Coumaroyl-CoA
	1 ↔ 12 2 ↔ 13 3 ↔ 14 4 ↔ 15 5 ↔ 16 6 ↔ 17 7 ↔ 18 8 ↔ 19 9 ↔ 20 10 ↔ 21 11 ↔ 22 12 ↔ 23 13 ↔ 24 14 ↔ 25 15 ↔ 26 32 ↔ 43 33 ↔ 44 34 ↔ 46 35 ↔ 45 36 ↔ 47 37 ↔ 48 38 ↔ 49 39 ↔ 50 40 ↔ 51 41 ↔ 52 42 ↔ 53 43 ↔ 54 44 ↔ 55 45 ↔ 56

ATP	<Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0	AMP
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15

trans-3- (4-Hydroxyphenyl) prop-2-enoic acid	<Mapping> AtomMap:BMMCBZ2Pk059$BMMCBZ2Pa016$0	4-Coumaroyl-CoA
	1 ↔ 1 2 ↔ 6 3 ↔ 5 4 ↔ 4 5 ↔ 3 6 ↔ 2 7 ↔ 7 8 ↔ 8 9 ↔ 9

CoA + ATP + Sinapic acid => Sinapoyl-CoA + AMP + Pyrophosphate
(links: CoA + ATP + trans-3- (4-Hydroxy-3,5-dimethoxyphenyl) prop-2-enoic acid = Sinapoyl-CoA + AMP)

CoA	<Mapping> AtomMap:BMCCPUAPf023$BMMCBZ4Sa013$0	Sinapoyl-CoA
	1 ↔ 16 2 ↔ 17 3 ↔ 18 4 ↔ 19 5 ↔ 20 6 ↔ 21 7 ↔ 22 8 ↔ 23 9 ↔ 24 10 ↔ 25 11 ↔ 26 12 ↔ 27 13 ↔ 28 14 ↔ 29 15 ↔ 30 32 ↔ 47 33 ↔ 48 34 ↔ 50 35 ↔ 49 36 ↔ 51 37 ↔ 52 38 ↔ 53 39 ↔ 54 40 ↔ 55 41 ↔ 56 42 ↔ 57 43 ↔ 58 44 ↔ 59 45 ↔ 60

ATP	<Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0	AMP
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15

trans-3- (4-Hydroxy-3,5-dimethoxyphenyl) prop-2-enoic acid	<Mapping> AtomMap:BMMCBZ4Sk009$BMMCBZ4Sa013$0	Sinapoyl-CoA
	1 ↔ 1 2 ↔ 6 3 ↔ 5 4 ↔ 4 5 ↔ 3 6 ↔ 2 7 ↔ 7 8 ↔ 8 9 ↔ 9 13 ↔ 15 16 ↔ 12

CoA + ATP + Caffeic acid => Caffeoyl-CoA + AMP + Pyrophosphate
(links: CoA + ATP + trans-3- (3,4-Dihydroxyphenyl) prop-2-enoic acid = Caffeoyl-CoA + AMP)

CoA	<Mapping> AtomMap:BMCCPUAPf023$BMMCBZ3Sa045$0	Caffeoyl-CoA
	1 ↔ 13 2 ↔ 14 3 ↔ 15 4 ↔ 16 5 ↔ 17 6 ↔ 18 7 ↔ 19 8 ↔ 20 9 ↔ 21 10 ↔ 22 11 ↔ 23 12 ↔ 24 13 ↔ 25 14 ↔ 26 15 ↔ 27 32 ↔ 44 33 ↔ 45 34 ↔ 47 35 ↔ 46 36 ↔ 48 37 ↔ 49 38 ↔ 50 39 ↔ 51 40 ↔ 52 41 ↔ 53 42 ↔ 54 43 ↔ 55 44 ↔ 56 45 ↔ 57

ATP	<Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0	AMP
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15

trans-3- (3,4-Dihydroxyphenyl) prop-2-enoic acid	<Mapping> AtomMap:BMMCBZ3Sk044$BMMCBZ3Sa045$0	Caffeoyl-CoA
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9

CoA	<Mapping> AtomMap:BMCCPUAPf023$BMMCBZ3Sa050$0	S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] (E) -3- (4-hydroxy-3-methoxyphenyl) prop-2-enethioic acid
	1 ↔ 14 2 ↔ 15 3 ↔ 16 4 ↔ 17 5 ↔ 18 6 ↔ 19 7 ↔ 20 8 ↔ 21 9 ↔ 22 10 ↔ 23 11 ↔ 24 12 ↔ 25 13 ↔ 26 14 ↔ 27 15 ↔ 28 32 ↔ 45 33 ↔ 46 34 ↔ 48 35 ↔ 47 36 ↔ 49 37 ↔ 50 38 ↔ 51 39 ↔ 52 40 ↔ 53 41 ↔ 54 42 ↔ 55 43 ↔ 56 44 ↔ 57 45 ↔ 58

ATP	<Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0	AMP
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15

trans-3- (4-Hydroxy-3-methoxyphenyl) prop-2-enoic acid	<Mapping> AtomMap:BMMCBZ3Sk049$BMMCBZ3Sa050$0	S- [2- [3- [ [4- [ [ [(2R,3S,4R,5R) -5- (6-Aminopurin-9-yl) -4-hydroxy-3-phosphonooxyoxolan-2-yl] methoxy-hydroxyphosphoryl] oxy-hydroxyphosphoryl] oxy-2-hydroxy-3,3-dimethylbutanoyl] amino] propanoylamino] ethyl] (E) -3- (4-hydroxy-3-methoxyphenyl) prop-2-enethioic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 13 ↔ 12

@@ Line 3: / Line 3: @@
 |SysName=4-coumarate:CoA ligase (AMP-forming)
 |names=&&4-coumarate-CoA ligase&&4-coumaroyl-CoA synthetase&&p-coumaroyl CoA ligase&&p-coumaryl coenzyme A synthetase&&feruloyl CoA ligase
+}}
+{{Enzyme/Reaction| reaction= CoA + ATP + trans-4-Hydroxy-cinnamic acid => 4-Coumaroyl-CoA + AMP + Pyrophosphate
+| list=
+&& BMCCPUAPf023$BMMCBZ2Pa016$0
+&& BMCCPUAP0022$BMCCPUAP0021$0
+&& BMMCBZ2Pk059$BMMCBZ2Pa016$0
+}}
+{{Enzyme/Reaction| reaction= CoA + ATP + Sinapic acid => Sinapoyl-CoA + AMP + Pyrophosphate
+| list=
+&& BMCCPUAPf023$BMMCBZ4Sa013$0
+&& BMCCPUAP0022$BMCCPUAP0021$0
+&& BMMCBZ4Sk009$BMMCBZ4Sa013$0
+}}
+{{Enzyme/Reaction| reaction= CoA + ATP + Caffeic acid => Caffeoyl-CoA + AMP + Pyrophosphate
+| list=
+&& BMCCPUAPf023$BMMCBZ3Sa045$0
+&& BMCCPUAP0022$BMCCPUAP0021$0
+&& BMMCBZ3Sk044$BMMCBZ3Sa045$0
+}}
+{{Enzyme/Reaction| reaction= CoA + ATP + Ferulic acid => Feruloyl-CoA + AMP + Pyrophosphate
+| list=
+&& BMCCPUAPf023$BMMCBZ3Sa050$0
+&& BMCCPUAP0022$BMCCPUAP0021$0
+&& BMMCBZ3Sk049$BMMCBZ3Sa050$0
 }}

IDs and Links
IUBMB	EC6
ExPaSy	NiceZyme 6.2.1.12