Enzyme:6.3.2.26

Revision as of 09:00, 2 February 2009

L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming,valine-inverting)
Systematic Name	L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming,valine-inverting)
Common Name	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase ACV synthetase

2 ATP + L-Valine + L-Cysteine + H2O = 2 AMP + L-Cysteinyl-D-valine + 2 Pyrophosphate
(links: ATP + (2S) -2-Amino-3-methylbutanoic acid + L-Cysteine = AMP + L-Cysteinyl-D-valine)

ATP	<Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0	AMP
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15

ATP	<Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0	AMP
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15

(2S) -2-Amino-3-methylbutanoic acid	<Mapping> AtomMap:BMAAB4AK0001$BMAXDP--0013$0	L-Cysteinyl-D-valine
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 5 5 ↔ 4 6 ↔ 6

L-Cysteine	<Mapping> AtomMap:BMAAS3SF0003$BMAXDP--0013$0	L-Cysteinyl-D-valine
	1 ↔ 7 2 ↔ 8 3 ↔ 9 4 ↔ 10 5 ↔ 11

ATP	<Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0	AMP
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15

(2S)-2-Aminohexanedioic acid	<Mapping> AtomMap:BMFYS6DAm009$BMAXTP--0006$0	(2S) -2-Amino-6- [ [1- [ [(2R) -1-hydroxy-3-methyl-1-oxobutan-2-yl] amino] -1-oxo-3-sulfanylpropan-2-yl] amino] -6-oxohexanoic acid
	1 ↔ 12 2 ↔ 13 3 ↔ 14 4 ↔ 15 5 ↔ 16 6 ↔ 17 7 ↔ 18

L-Cysteinyl-D-valine	<Mapping> AtomMap:BMAXDP--0013$BMAXTP--0006$0	(2S) -2-Amino-6- [ [1- [ [(2R) -1-hydroxy-3-methyl-1-oxobutan-2-yl] amino] -1-oxo-3-sulfanylpropan-2-yl] amino] -6-oxohexanoic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 5 5 ↔ 4 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11

@@ Line 3: / Line 3: @@
 |SysName=L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming,valine-inverting)
 |names=&&N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase&&L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase&&ACV synthetase
+}}
+{{Enzyme/Reaction| reaction= 2 ATP + L-Valine + L-Cysteine + H2O = 2 AMP + L-Cysteinyl-D-valine + 2 Pyrophosphate
+| list=
+&& BMCCPUAP0022$BMCCPUAP0021$0
+&& BMCCPUAP0022$BMCCPUAP0021$0
+&& BMAAB4AK0001$BMAXDP--0013$0
+&& BMAAS3SF0003$BMAXDP--0013$0
+}}
+{{Enzyme/Reaction| reaction= ATP + L-2-Amino-adipic acid + L-Cysteinyl-D-valine = AMP + N-[L-5-amino-5-carboxy-pentanoyl]-L-cysteinyl-D-valine + Pyrophosphate
+| list=
+&& BMCCPUAP0022$BMCCPUAP0021$0
+&& BMFYS6DAm009$BMAXTP--0006$0
+&& BMAXDP--0013$BMAXTP--0006$0
 }}

IDs and Links
IUBMB	EC6
ExPaSy	NiceZyme 6.3.2.26