PKS:AN8383

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(update information: gene cluster;update references-Andersen 2013)
 
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|species=Aspergillus nidulans FGSC A4
 
|species=Aspergillus nidulans FGSC A4
 
|taxonomy=Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Pezizomycotina; Leotiomyceta; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; Emericella
 
|taxonomy=Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomyceta; Pezizomycotina; Leotiomyceta; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; Emericella
−
|product=
+
|product=austinol, dehydroaustinol
 
|GenBank=XP_681652
 
|GenBank=XP_681652
 
|UniProt=C8VE81
 
|UniProt=C8VE81
 
|UniRef90=C8VE81
 
|UniRef90=C8VE81
 
|UniRef50=C8VE81
 
|UniRef50=C8VE81
−
|geneName=pks11
+
|geneName=pks11(ausA)
 
|MAPSI=KS-AT-ACP
 
|MAPSI=KS-AT-ACP
−
|CDD=KS-AT-(DH)-PP-ME(SAM)-Aes(EL)
+
|CDD=KS-AT-(DH)-PP-ME-(Aes/EL)
 +
|ITERDB=KS-AT-ACP
 +
|InferredDomain=SAT-KS-AT-PT-ACP-ME-TE
 
|class=PRPKS
 
|class=PRPKS
−
|reliability=
+
|reliability=Verified
 
|description=
 
|description=
−
|information=other accession number: CBF80428, EAA67005. Different with ANid15(XP_658127)
+
|information=Other accession number: CBF80428, EAA67005. Different with ANIA 00523(XP_658127). DH and Aes/EL domain from CDD are incomplete. ANIA08383 is possibly classified into NRPKS. Predicted gene cluster:7 genes; known gene cluster: 4 genes.
 
|length=2476
 
|length=2476
−
|references=\*Schmitt.+2008$
+
|references=\*Schmitt.+2008$~\*Lo.+2012$~\*Ahuja.+2012$~\*Andersen.+2013$
 
}}
 
}}
 
{{{{NAMESPACE}}/Footer}}
 
{{{{NAMESPACE}}/Footer}}

Latest revision as of 17:39, 26 March 2013

Polyketide Top Species List UniRef90 Class UniRef50 Class Gene Class Domains
(by CDD) 		Domains
(by MAPSI)
Aspergillus nidulans FGSC A4 (GenBank XP_681652) all species
Class PRPKS (length: 2476) all classes   Class in KS domain phylogeny Reliability Verified
Product austinol, dehydroaustinol GeneName pks11(ausA)
UniProt,UniRef90 C8VE81 , C8VE81 UniRef50 C8VE81
Domain by MAPSI KS-AT-ACP

(notation help / all patterns)

Domain by CDD KS-AT-(DH)-PP-ME-(Aes/EL)

(notation help / all patterns)

Domain by ITER-DB KS-AT-ACP

(notation help / all patterns)

Estimated Domain SAT-KS-AT-PT-ACP-ME-TE
Description
Information Other accession number: CBF80428, EAA67005. Different with ANIA 00523(XP_658127). DH and Aes/EL domain from CDD are incomplete. ANIA08383 is possibly classified into NRPKS. Predicted gene cluster:7 genes; known gene cluster: 4 genes.
References
  • Ahuja M, Chiang YM, Chang SL, Praseuth MB, Entwistle R, Sanchez JF, Lo HC, Yeh HH, Oakley BR, Wang CC: Illuminating the diversity of aromatic polyketide synthases in aspergillus nidulans. J Am Chem Soc, 2012
  • Andersen M R, Nielsen J B, Klitgaard A, Petersen L M, Zachariasen M, Hansen T J, Blicher L H, Gotfredsen C H, Larsen T O, Nielsen K F, Mortensen U H: Accurate prediction of secondary metabolite gene clusters in filamentous fungi. Proc Natl Acad Sci U S A 110(1): E99-107. 2013
  • Lo HC, Entwistle R, Guo CJ, Ahuja M, Szewczyk E, Hung JH, Chiang YM, Oakley BR, Wang CC: Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in aspergillus nidulans. J Am Chem Soc 134(10):4709-4720, 2012
  • Schmitt I, Kautz S, Lumbsch HT: 6-MSAS-like polyketide synthase genes occur in lichenized ascomycetes. Mycol Res 112:289-296, 2008
Link AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)

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