Enzyme:6.3.2.11

Revision as of 09:00, 2 February 2009

L-histidine:beta-alanine ligase (AMP-forming)
Systematic Name	L-histidine:beta-alanine ligase (AMP-forming)
Common Name	carnosine synthase carnosine synthetase carnosine-anserine synthetase homocarnosine-carnosine synthetase carnosine-homocarnosine synthetase

ATP + N(pai)-Methyl-L-histidine + beta-Alanine => AMP + L-Anserine + Pyrophosphate
(links: ATP + L-Anserine + 3-Amino-propanoic acid = AMP + (2S) -2-Amino-3- (3-methylimidazol-4-yl) propanoic acid + L-Anserine)

ATP	<Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0	AMP
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15

L-Anserine	<Mapping> AtomMap:BMAXDP--0011$BMACIZANr002$0	(2S) -2-Amino-3- (3-methylimidazol-4-yl) propanoic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10

3-Amino-propanoic acid	<Mapping> AtomMap:BMAAS3AK0001$BMAXDP--0011$1 (2nd)	L-Anserine
	1 ↔ 11 2 ↔ 12 3 ↔ 13 4 ↔ 14

ATP	<Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0	AMP
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15

(2S) -2- (3-Aminopropanoylamino) -5- (diaminomethylideneamino) pentanoic acid	<Mapping> AtomMap:BMAXDP--0003$BMAAS5AN0003$0	L-Arginine
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 10 10 ↔ 9

3-Amino-propanoic acid	<Mapping> AtomMap:BMAAS3AK0001$BMAXDP--0003$1 (2nd)	(2S) -2- (3-Aminopropanoylamino) -5- (diaminomethylideneamino) pentanoic acid
	1 ↔ 11 2 ↔ 12 3 ↔ 13 4 ↔ 14

ATP + L-Lysine + beta-Alanine => AMP + beta-Alanyl-L-lysine + Pyrophosphate
(links: ATP + beta-Alanyl-L-lysine + 3-Amino-propanoic acid = AMP + (2S) -2,6-Diaminohexanoic acid + beta-Alanyl-L-lysine)

ATP	<Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0	AMP
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15

beta-Alanyl-L-lysine	<Mapping> AtomMap:BMAXDP--0004$BMAAS6AN0005$0	(2S) -2,6-Diaminohexanoic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8

3-Amino-propanoic acid	<Mapping> AtomMap:BMAAS3AK0001$BMAXDP--0004$1 (2nd)	beta-Alanyl-L-lysine
	1 ↔ 9 2 ↔ 10 3 ↔ 11 4 ↔ 12

ATP	<Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0021$0	AMP
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15

L-Carnosine	<Mapping> AtomMap:BMAXDP--0012$BMACIZ--0002$0	(2S) -2-Amino-3- (1H-imidazol-5-yl) propanoic acid
	1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9

3-Amino-propanoic acid	<Mapping> AtomMap:BMAAS3AK0001$BMAXDP--0012$1 (2nd)	L-Carnosine
	1 ↔ 10 2 ↔ 11 3 ↔ 12 4 ↔ 13

@@ Line 3: / Line 3: @@
 |SysName=L-histidine:beta-alanine ligase (AMP-forming)
 |names=&&carnosine synthase&&carnosine synthetase&&carnosine-anserine synthetase&&homocarnosine-carnosine synthetase&&carnosine-homocarnosine synthetase
+}}
+{{Enzyme/Reaction| reaction= ATP + N(pai)-Methyl-L-histidine + beta-Alanine => AMP + L-Anserine + Pyrophosphate
+| list=
+&& BMCCPUAP0022$BMCCPUAP0021$0
+&& BMAXDP--0011$BMACIZANr002$0
+&& BMAAS3AK0001$BMAXDP--0011$1
+}}
+{{Enzyme/Reaction| reaction= ATP + L-Arginine + beta-Alanine => AMP + beta-Alanyl-L-arginine + Pyrophosphate
+| list=
+&& BMCCPUAP0022$BMCCPUAP0021$0
+&& BMAXDP--0003$BMAAS5AN0003$0
+&& BMAAS3AK0001$BMAXDP--0003$1
+}}
+{{Enzyme/Reaction| reaction= ATP + L-Lysine + beta-Alanine => AMP + beta-Alanyl-L-lysine + Pyrophosphate
+| list=
+&& BMCCPUAP0022$BMCCPUAP0021$0
+&& BMAXDP--0004$BMAAS6AN0005$0
+&& BMAAS3AK0001$BMAXDP--0004$1
+}}
+{{Enzyme/Reaction| reaction= ATP + L-Histidine + beta-Alanine => AMP + L-Carnosine + Pyrophosphate
+| list=
+&& BMCCPUAP0022$BMCCPUAP0021$0
+&& BMAXDP--0012$BMACIZ--0002$0
+&& BMAAS3AK0001$BMAXDP--0012$1
 }}

IDs and Links
IUBMB	EC6
ExPaSy	NiceZyme 6.3.2.11