Enzyme:6.3.2.17

Upper Levels: EC6.-.-.- Ligases. : EC6.3.-.- Forming carbon-nitrogen bonds. : EC6.3.2.- Acid--D-amino-acid ligases (peptide synthases).

IDs and Links
IUBMB	EC6
ExPaSy	NiceZyme 6.3.2.17

tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming)
Systematic Name	tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming)
Common Name	tetrahydrofolylpolyglutamate synthase folate polyglutamate synthetase formyltetrahydropteroyldiglutamate synthetase N10-formyltetrahydropteroyldiglutamate synthetase folylpoly-gamma-glutamate synthase

ATP + 10-Formyl-tetrahydro-folic acid + L-Glutamic acid => ADP + 10-Formyl-THF-L-glutamic acid + Orthophosphate (links: ATP + 10-Formyl-tetrahydro-folic acid + (2S) -2-Amino-pentanedioic acid = ADP + 2- [ [4- [ [4- [(2-Amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl) methyl-formylamino] benzoyl] amino] -5-hydroxy-5-oxopentanoyl] amino] pentanedioicacid)

ATP <Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0020$0 ADP 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 10-Formyl-tetrahydro-folic acid <Mapping> AtomMap:BMCCPTFOo001$BMCCPTFOo002$0 2- [ [4- [ [4- [(2-Amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl) methyl-formylamino] benzoyl] amino] -5-hydroxy-5-oxopentanoyl] amino] pentanedioicacid 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 15 15 ↔ 20 16 ↔ 19 17 ↔ 18 18 ↔ 17 19 ↔ 16 20 ↔ 21 21 ↔ 22 22 ↔ 23 23 ↔ 24 24 ↔ 25 25 ↔ 26 26 ↔ 27 27 ↔ 14 (2S) -2-Amino-pentanedioic acid <Mapping> AtomMap:BMAAS5CA0007$BMCCPTFOo002$0 2- [ [4- [ [4- [(2-Amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl) methyl-formylamino] benzoyl] amino] -5-hydroxy-5-oxopentanoyl] amino] pentanedioicacid 1 ↔ 28 2 ↔ 29 3 ↔ 30 4 ↔ 31 5 ↔ 32 6 ↔ 33

ATP + 10-Formyl-THF-L-glutamic acid + L-Glutamic acid => ADP + 10-Formyl-THF-poly-L-glutamic acid + Orthophosphate (links: ATP + 2- [ [4- [ [4- [(2-Amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl) methyl-formylamino] benzoyl] amino] -5-hydroxy-5-oxopentanoyl] amino] pentanedioicacid + (2S) -2-Amino-pentanedioic acid = ADP + 10-Formyl-THF-poly-L-glutamic acid)

ATP <Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0020$0 ADP 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 2- [ [4- [ [4- [(2-Amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl) methyl-formylamino] benzoyl] amino] -5-hydroxy-5-oxopentanoyl] amino] pentanedioicacid <Mapping> AtomMap:BMCCPTFOo002$BMCCPTFOo003$0 10-Formyl-THF-poly-L-glutamic acid 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 20 17 ↔ 19 18 ↔ 18 19 ↔ 17 20 ↔ 16 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 27 ↔ 27 28 ↔ 28 29 ↔ 29 30 ↔ 30 31 ↔ 31 32 ↔ 32 33 ↔ 33 (2S) -2-Amino-pentanedioic acid <Mapping> AtomMap:BMAAS5CA0007$BMCCPTFOo003$0 10-Formyl-THF-poly-L-glutamic acid 1 ↔ 34 2 ↔ 35 3 ↔ 36 4 ↔ 37 5 ↔ 38 6 ↔ 39

ATP + 7,8-Dihydro-pteroic acid + L-Glutamic acid => ADP + 7,8-Dihydro-folic acid + Orthophosphate (links: ATP + 7,8-Dihydro-pteroic acid + (2S) -2-Amino-pentanedioic acid = ADP + 7,8-Dihydro-folic acid)

ATP <Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0020$0 ADP 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 7,8-Dihydro-pteroic acid <Mapping> AtomMap:BMCCPTPTk014$BMCCPTFO0011$0 7,8-Dihydro-folic acid 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 19 16 ↔ 18 17 ↔ 17 18 ↔ 16 19 ↔ 15 20 ↔ 20 (2S) -2-Amino-pentanedioic acid <Mapping> AtomMap:BMAAS5CA0007$BMCCPTFO0011$0 7,8-Dihydro-folic acid 1 ↔ 22 2 ↔ 23 3 ↔ 24 4 ↔ 25 5 ↔ 26 6 ↔ 21

ATP + L-Tetrahydro-folic acid + L-Glutamic acid => ADP + Tetrahydrofolyl-[Glu] + Orthophosphate (links: ATP + L-Tetrahydro-folic acid + (2S) -2-Amino-pentanedioic acid = ADP + 2- [ [4- [ [4- [(2-Amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl) methylamino] benzoyl] amino] -5-hydroxy-5-oxopentanoyl] amino] pentanedioic acid)

ATP <Mapping> AtomMap:BMCCPUAP0022$BMCCPUAP0020$0 ADP 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 L-Tetrahydro-folic acid <Mapping> AtomMap:BMCCPTFO0013$BMCCPTFOk015$0 2- [ [4- [ [4- [(2-Amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl) methylamino] benzoyl] amino] -5-hydroxy-5-oxopentanoyl] amino] pentanedioic acid 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 19 16 ↔ 18 17 ↔ 17 18 ↔ 16 19 ↔ 15 20 ↔ 20 21 ↔ 21 22 ↔ 22 23 ↔ 23 24 ↔ 24 25 ↔ 25 26 ↔ 26 (2S) -2-Amino-pentanedioic acid <Mapping> AtomMap:BMAAS5CA0007$BMCCPTFOk015$0 2- [ [4- [ [4- [(2-Amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl) methylamino] benzoyl] amino] -5-hydroxy-5-oxopentanoyl] amino] pentanedioic acid 1 ↔ 28 2 ↔ 29 3 ↔ 30 4 ↔ 31 5 ↔ 32 6 ↔ 27