Enzyme:1.2.4.2

Upper Levels: EC1.-.-.- Oxidoreductases. : EC1.2.-.- Acting on the aldehyde or oxo group of donors. : EC1.2.4.- With a disulfide as acceptor.

IDs and Links
IUBMB	EC1
ExPaSy	NiceZyme 1.2.4.2

2-oxoglutarate:[dihydrolipoyllysine-residuesuccinyltransferase]-lipoyllysine 2-oxidoreductase(decarboxylating, acceptor-succinylating)
Systematic Name	2-oxoglutarate:[dihydrolipoyllysine-residuesuccinyltransferase]-lipoyllysine 2-oxidoreductase(decarboxylating, acceptor-succinylating)
Common Name	oxoglutarate dehydrogenase (succinyl-transferring) 2-ketoglutarate dehydrogenase 2-oxoglutarate: lipoate oxidoreductase 2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating andacceptor-succinylating) alpha-ketoglutarate dehydrogenase

TPP + 2-Oxo-adipic acid = 2-(Glutaryl)-thiamine diphosphate + CO2 (links: TPP + CO2 + 2-Oxo-adipic acid = 2-Glutarylthiamine diphosphate + 2-Oxo-adipic acid)

TPP <Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e004$0 2-Glutarylthiamine diphosphate 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17 CO2 <Mapping> AtomMap:BMXXSX--0007$BMFYS6DAp004$0 2-Oxo-adipic acid 1 ↔ 1 2-Oxo-adipic acid <Mapping> AtomMap:BMFYS6DAp004$BMMCTZ--e004$0 2-Glutarylthiamine diphosphate 2 ↔ 18 3 ↔ 19 4 ↔ 20 5 ↔ 21 6 ↔ 22

2-(Glutaryl)-thiamine diphosphate + Lipoamide = TPP + S-Glutaryl-dihydro-lipoamide (links: TPP + Lipoamide + 2-Glutarylthiamine diphosphate = 2-Glutarylthiamine diphosphate + 5- (8-Amino-8-oxo-3-sulfanyloctyl) sulfanyl-5-oxopentanoic acid)

TPP <Mapping> AtomMap:BMMCTZ--e012$BMMCTZ--e004$0 2-Glutarylthiamine diphosphate 1 ↔ 1 2 ↔ 2 3 ↔ 3 4 ↔ 4 5 ↔ 5 6 ↔ 6 7 ↔ 7 8 ↔ 8 9 ↔ 9 10 ↔ 10 11 ↔ 11 12 ↔ 12 13 ↔ 13 14 ↔ 14 15 ↔ 15 16 ↔ 16 17 ↔ 17 Lipoamide <Mapping> AtomMap:BMMCHC--l024$BMFYB8AMf005$0 5- (8-Amino-8-oxo-3-sulfanyloctyl) sulfanyl-5-oxopentanoic acid 1 ↔ 10 2 ↔ 4 3 ↔ 3 4 ↔ 2 5 ↔ 1 6 ↔ 5 7 ↔ 6 8 ↔ 7 9 ↔ 8 10 ↔ 9 11 ↔ 11 2-Glutarylthiamine diphosphate <Mapping> AtomMap:BMMCTZ--e004$BMFYB8AMf005$0 5- (8-Amino-8-oxo-3-sulfanyloctyl) sulfanyl-5-oxopentanoic acid 18 ↔ 16 19 ↔ 15 20 ↔ 14 21 ↔ 13 22 ↔ 12