PKS:An14g04850

Polyketide Top

Species List

UniRef90 Class

UniRef50 Class

Gene Class

Domains (by CDD)

Domains (by MAPSI)

Aspergillus niger CBS 513.88 (GenBank XP_001401108) all species
Class	NRPS-PKS (length: 1869) all classes   Class 02.NRPS-PKS(NFC) in KS domain phylogeny	Reliability
Product		GeneName
UniProt,UniRef90	A2R3M8 , -	UniRef50	-
Domain by MAPSI	ACP-KS-AT-ACP (notation help / all patterns)
Domain by CDD	LuxE-PP-KS-AT-PP (notation help / all patterns)
Domain by ITER-DB	{{{ITERDB}}} (notation help / all patterns)
Estimated Domain
Description	hypothetical protein An14g04850 [Aspergillus niger]
Information	domain-AA-adenyl-dom and PP before KS . Title: strong similarity to pimaricin polyketide synthase pimS2 - Streptomyces natalensis; Catalytic activity: polyketide synthases are multifunctional enzymes-containing oxidoreductase-transferase and dehydratase activity; some of the typical domains present in polyketide synthases are recognized in the predicted ORF.; Function: pimS2 of S. natalensis is involved in the biosynthesis of the polyene macrolide pimaricin-important in the food industry as a preservative to prevent mould contamination of foods.; Pathway: polyketides are generated from acetate by a pathway similar to the fatty acid metabolism-where some reduction or dehydratation reactions can be suppressed at specific biosynthetic steps-resulting in a much wider range of products-constituting a large family of often biologically active secondary metabolites.; Similarity: the predicted ORF shows strong similarity to different fungal polyketide synthases.?
References	Pel HJ, de Winde JH, Archer DB, Dyer PS, Hofmann G, Schaap PJ, Turner G, de Vries RP, Albang R, Albermann K, Andersen MR, Bendtsen JD, Benen JA, van den Berg M, Breestraat S, Caddick MX, Contreras R, Cornell M, Coutinho PM, Danchin EG, Debets AJ, Dekker P, van Dijck PW, van Dijk A, Dijkhuizen L, Driessen AJ, d'Enfert C, Geysens S, Goosen C, Groot GS, de Groot PW, Guillemette T, Henrissat B, Herweijer M, van den Hombergh JP, van den Hondel CA, van der Heijden RT, van der Kaaij RM, Klis FM, Kools HJ, Kubicek CP, van Kuyk PA, Lauber J, Lu X, van der Maarel MJ, Meulenberg R, Menke H, Mortimer MA, Nielsen J, Oliver SG, Olsthoorn M, Pal K, van Peij NN, Ram AF, Rinas U, Roubos JA, Sagt CM, Schmoll M, Sun J, Ussery D, Varga J, Vervecken W, van de Vondervoort PJ, Wedler H, Wosten HA, Zeng AP, van Ooyen AJ, Visser J, Stam H: Genome sequencing and analysis of the versatile cell factory aspergillus niger cbs 513.88. Nat Biotechnol 25(2):221-231, 2007
Link	AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)