PKS:Fung057

Polyketide Top

Species List

UniRef90 Class

UniRef50 Class

Gene Class

Domains (by CDD)

Domains (by MAPSI)

Mycosphaerella pini (GenBank AAZ95017) all species
Class	NRPKS (length: 2399) all classes   Class 16.NRPKS_I(9) in KS domain phylogeny	Reliability
Product	dothistromin	GeneName	pksA
UniProt,UniRef90	[1] , [2]	UniRef50	[3]
Domain by MAPSI	KS-AT-ACP-ACP-ACP-CYC (notation help / all patterns)
Domain by CDD	KS-AT-PP-PP-PP-TE (notation help / all patterns)
Domain by ITER-DB	KS-AT-ACP-ACP-ACP-CYC (notation help / all patterns)
Estimated Domain	SAT-KS-AT-PT-ACP-ACP-ACP-TE/CLC
Description
Information	Mycosphaerella pini (anamorph: Dothistroma septosporum).Dothistromin is a mycotoxin that is remarkably similar in structure to versicolorin B, a precursor of both aflatoxin and sterigmatocystin.
References	Ahuja M, Chiang YM, Chang SL, Praseuth MB, Entwistle R, Sanchez JF, Lo HC, Yeh HH, Oakley BR, Wang CC: Illuminating the diversity of aromatic polyketide synthases in aspergillus nidulans. J Am Chem Soc, 2012 Fisch KM, Gillaspy AF, Gipson M, Henrikson JC, Hoover AR, Jackson L, Najar FZ, Wagele H, Cichewicz RH: Chemical induction of silent biosynthetic pathway transcription in aspergillus niger. J Ind Microbiol Biotechnol 36(9):1199-1213, 2009 Li Y, Image, II, Xu W, Image I, Tang Y: Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem 285(30):22764-22773, 2010 Schwelm A, Bradshaw RE: Genetics of dothistromin biosynthesis of dothistroma septosporum: An update. Toxins 2(11):2680-2698, 2010
Link	AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)