Doc:Labdane
From Metabolomics.JP
Labdanes refers to a class of diterpenes with a 6-membered bicyclic structure. They are found in many plant families, especially Zingiberaceae and Cupressaceae. Some are known for their antibacterial, platelet aggregation inhibitory, or 5-lipoxygenase inhibitory, or anticancer activity.
Distribution
- Labdanes in Zingiberaceae
| Plants | labda-8(17),12-diene- 15,16 dial (and diolide) |
coronarin E | coronarin B, D | |
|---|---|---|---|---|
| Curcuma | C. longa (used in Kampo, TCM) |
○ leaves[1], ×rhizome[2] | ○ rhizome[2] | |
| C. zedoaria (used in TCM) |
× rhizome[2] | × rhizome[2] | ||
| C. mangga | ○ rhizome[3] | × (but zerumin B) | ||
| Hedychium | H.coronarium (used in Ayurveda, TCM) |
○ rhizome[4][5] | ○ rhizome[6] | ○ rhizome[4][5] |
Bioactivity
- labda-8(17),12-diene-15,16 dial ... antifungal activity against Candida albicans at 1 μg/mL, growth inhibition of Candida kruseii and C. parapsilosis at 25 mu;g/mL, mosquitocidal activity on Aedes aegyptii larvae at 10 μg / mL [1]
- References
- ↑ 1.0 1.1 Roth, Chandra, Nair (1998) J Nat Prod 61:542-545
- ↑ 2.0 2.1 2.2 2.3 Sirat, Masri, Rahman (1994) Phytochem 36(3):699-701
- ↑ Abas, Lajis, Shaari, Israf, Stanslas, Yusuf, Raof (2005) from the website
- ↑ 4.0 4.1 Nakatani, Kikuzaki, Yamaji, Yoshio, Kitora, Okada, Padolina (1994) Phytochem 37(5):1383-1388
- ↑ 5.0 5.1 Chimnoi, Pisutjaroenpong, Ngiwsara, Dechtrirut, Chokchaichamnankit, Khunnawutmanotham, Mahidol, Techasakul (2008) Nat Prod Res 22(14):1249-1256
- ↑ Matuda, Morikawa, Sakamoto, Toguchida, Yoshikawa (2002) Bioorganic & Medicinal Chem 10:2527-2534
