PKS:Bact36

Polyketide Top

Species List

UniRef90 Class

UniRef50 Class

Gene Class

Domains (by CDD)

Domains (by MAPSI)

Saccharopolyspora erythraea NRRL 2338 (GenBank YP_001107644) all species
Class	iPKS-6-MSAS (length: 1738) all classes   Class 03b_bMSAS in KS domain phylogeny	Reliability	identified
Product	Mellein	GeneName	pks8
UniProt,UniRef90	[1] , [2]	UniRef50	[3]
Domain by MAPSI	KS-AT-DH-KR-ACP (notation help / all patterns)
Domain by CDD	KS-AT-DH-KR-PP (notation help / all patterns)
Domain by ITER-DB	{{{ITERDB}}} (notation help / all patterns)
Estimated Domain	KS-AT-TH-KR-ACP
Description	iterative type I polyketide synthase [Saccharopolyspora erythraea NRRL 2338]
Information	SACE5532 (or pks8) catalyzes the formation of Mellein (3,4-dihydro-8-hydroxy-3-methylisocoumarin, 1). Notably, the KR domain alone is able to recognize and differentiate the polyketide intermediates.
References	Oliynyk M, Samborskyy M, Lester JB, Mironenko T, Scott N, Dickens S, Haydock SF and Leadlay PF: Complete genome sequence of the erythromycin-producing bacterium saccharopolyspora erythraea nrrl23338. Nat Biotechnol 25(4):447-453, 2007 Schmitt I, Lumbsch HT: Ancient horizontal gene transfer from bacteria enhances biosynthetic capabilities of fungi. PLoS One 4:e4437, 2009 Sun H, Ho CL, Ding F, Soehano I, Liu XW and Liang ZX: Synthesis of (r)-mellein by a partially reducing iterative polyketide synthase. J Am Chem Soc 134(29):11924-11927, 2012
Link	AspGD

This work is performed by ShuHsi Lin (TW), Toshitaka Kumagai and Masanori Arita (JP)