P450:CYP51
From Metabolomics.JP
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Arabidopsis (シロイヌナズナ) |
Oryza (イネ) |
Species-sequence information is taken from Cytochrome P450 Homepage by Dr. Nelson. (last update 2009/06/20)
51 Family
CYP51 encodes sterol 14alpha-demethylase, an essential enzyme for cholesterol and ergosterol biosynthesis, and is possessed by most fungi, plants, and slime molds. In microbes, it is an important drug target because the inhibition of its activity leads to blocks the synthesis of membrane lipids. On the other hand, nematodes and insects lack this gene.
The following text is reproduced from Dr. Nelson's page.
CYP51s were originally all called CYP51, because only one gene was found per species and they all seemed to be in this one conserved family. However, rice had many CYP51s in at least two sequence groups, so subfamilies have been designated for CYP51s. These are not the typical subfamilies, but only one subfamily is created for each major taxonomic group.
- CYP51A for animals,
- CYP51B for bacteria,
- CYP51C for Chromista,
- CYP51D for Dictyostelium,
- CYP51E for Euglenozoa,
- CYP51F for fungi.
Those groups with only one CYP51 per species are all called by one name:
- CYP51A1 is for all animal CYP51s since they are orthologous.
- The same is true for CYP51B, C, D, E and F.
- CYP51G (green plants) and CYP51Hs (monocots only so far) have individual sequence numbers.
- CYP51G1 refers to the typical CYP51 14 alpha-demethylase gene in plants, usually in one copy per species. A few species have extra CYP51G sequences.
- CYP51H is another group of related sequences that probably do not
have the same function as CYP51G. There are many of these in rice.
<<First Family <Previous Family
| ID | Species | Family | Order | Description
|
|---|---|---|---|---|
| CYP51G1 | Brassicaceae | Brassicales | GenEMBL AC007296 comp(52507-54167) | |
| CYP51G1 |
|
GenEMBL ESTs BI717817 BU649818 BI726293 BM001590 BI718677 AV642299 | ||
| CYP51G1 |
|
JGI model estExt_Genewise1.C_30095$$Volca1 | ||
| CYP51G1 |
|
EuGene.1200010398$$MicpuN3 at JGI | ||
| CYP51G1 |
|
estExt_fgenesh1_pg.C_100222$$MicpuC2 at JGI | ||
| CYP51G1 |
|
e_gw1.11.00.152.1$$Ostta4 at JGI | ||
| CYP51G1 |
|
e_gwEuk.11.159.1$$Ost9901_3 at JGI | ||
| CYP51G1 |
|
Funariaceae | Funariales | ESTs BJ585158.1 BJ591215.1 BJ592754.1 BJ963427.1 BJ165255.1 BJ157286.1 |
| CYP51G1v1 |
|
Solanaceae | Solanales | GenEMBL AF116915.1 |
| CYP51G1v2 |
|
Solanaceae | Solanales | GenEMBL AY065641.1 |
| CYP51G1 | Caricaceae | Brassicales | supercontig_119:252784,254990 | |
| CYP51G1 | Vitaceae | Vitales | AM475390.2, CAAP02000381.1 | |
| CYP51G1 |
|
Poaceae | Poales | GenEMBL AB025047 |
| CYP51G1 |
|
Poaceae | Poales | GenEMBL aaaa01012243.1 Indica rice genome |
| CYP51G1 |
|
Pinaceae | Coniferales | GenEMBL BF517195.1 AW984874.1 AW626637.1 C-term fragments |
| CYP51G1 | Poaceae | Poales | GenEMBL U74319 | |
| CYP51G1 |
|
Poaceae | Poales | GenEMBL Y09291 (1655bp) |
| CYP51G1 |
|
Poaceae | Poales | GenEMBL Y09292 (1231bp) |
| CYP51G1 | Poaceae | Poales | GenEMBL T12664 (EST fragment) | |
| CYP51G1 |
|
Poaceae | Poales | No accession number |
| CYP51G1 |
|
Salicaceae | Malpighiales | |
| CYP51G1 |
|
Solanaceae | Solanales | AY552551 |
| CYP51G1 |
|
Cucurbitaceae | Cucurbitales | AM722680 AM721153.2 |
| CYP51G1 |
|
Pedaliaceae | Lamiales | No accession number |
| CYP51G1 | Malvaceae | Malvales | DQ122177 | |
| CYP51G1 |
|
Ebenaceae | Ericales | DC586067.1, DC585117.1 |
| CYP51G1 |
|
Rubiaceae | Gentianales | EE193728.1 |
| CYP51G1 |
|
Magnoliaceae | Magnoliales | FD493672.1 FD498629.1 |
| CYP51G1 |
|
Aristolochiaceae | Piperales | FD760060.1 ends do not match |
| CYP51G1 |
|
Zamiaceae | Cycadales | FD774927.1 FD769109.1 |
| CYP51G2 | Brassicaceae | Brassicales | GenEMBL AC002329 Complete sequence | |
| CYP51G3 |
|
Poaceae | Poales | GenEMBL AY022669.1 |
| CYP51G4P |
|
Poaceae | Poales | GenEMBL AP003866.1b |
| CYP51G5 |
|
Salicaceae | Malpighiales | |
| CYP51G6 | Vitaceae | Vitales | CAAP02000072.1 | |
| CYP51G7P | Vitaceae | Vitales | CAAP02006913.1 | |
| CYP51G1 |
|
Fabaceae | Fabales | GenEMBL DQ335779 also GenPept ABC59074 |
| CYP51G1 |
|
Fabaceae | Fabales | DQ340249 |
| CYP51G1 |
|
Selaginellaceae | Selaginellales | traces 724390578, 890688186, 719688188 |
| CYP51G1 |
|
Pteridaceae | Polypodiales | GenEMBL CV734775.1 CV734906.1 ESTs |
| CYP51G1 |
|
Asteraceae | Asterales | GenEMBL DW082409 DY973804.1 ESTs |
| CYP51G1 |
|
Euphorbiaceae | Malpighiales | GenEMBL AASG01019728 (WGS) |
| CYP51G1 |
|
Myrtaceae | Myrtales | GenEMBL CT983870 EST |
| CYP51G1 |
|
GenEMBL DR174877 | ||
| CYP51G1 |
|
Rosaceae | Rosales | EB130903.1 EST |
| CYP51G1 |
|
Rutaceae | Sapindales | GenEMBL DY300918 |
| CYP51G1 |
|
Malvaceae | Malvales | GenEMBL DT574647 |
| CYP51G1 |
|
Aizoaceae | Caryophyllales | GenEMBL CA839975 |
| CYP51G1 |
|
Ranunculaceae | Ranunculales | GenEMBL DT767027.1 EST |
| CYP51G1 |
|
Fagaceae | Fagales | GenEMBL DN949857.1 |
| CYP51G1 |
|
Pteridaceae | Polypodiales | BP920200 |
| CYP51H1 |
|
Poaceae | Poales | GenEMBL AP005448.1b AP005188.2c |
| CYP51H2P |
|
Poaceae | Poales | GenEMBL AP005188.2b AP005448.1a |
| CYP51H3 |
|
Poaceae | Poales | GenEMBL AP005188.2a |
| CYP51H4 |
|
Poaceae | Poales | GenEMBL AP004890.1 |
| CYP51H5 |
|
Poaceae | Poales | GenEMBL AP004090.1 |
| CYP51H6 |
|
Poaceae | Poales | GenEMBL AC108875.1a |
| CYP51H7 |
|
Poaceae | Poales | GenEMBL AC108875.1b |
| CYP51H8 |
|
Poaceae | Poales | GenEMBL AC108875.1c |
| CYP51H9 |
|
Poaceae | Poales | GenEMBL AP003866.1a |
| CYP51H10 |
|
Poaceae | Poales | GenEMBL DQ680852 |
| CYP51H11 |
|
Poaceae | Poales | No accession number |
| CYP51H12 | Poaceae | Poales | EU954990 | |
| CYP55B1 | See Chlamy page
|
Functions
- CYP51, sterol 14-demethylase; obtusifoliol-14alpha-demethylase,
Links
- CYPedia CYP51 Functional Prediction (Cytochrome P450 Expression Database using Arabidopsis) by IBMP Strasbourg.
